marie replied: "crazy, if It helps you that's great, but the stomach side effects are bad enough, motrin is better!"

k replied: "Clinoril - NSAID Renal Insufficiency Sulindac pharmacokinetics have been investigated in patients with renal insufficiency. The disposition of sulindac was studied in end-stage renal disease patients requiring hemodialysis. Plasma concentrations of sulindac and it sulfone metabolite were comparable to those of normal healthy volunteers whereas concentrations of the active sulfide metabolite were significantly reduced. Plasma protein binding was reduced and the AUC of the unbound sulfide metabolite was about half that in healthy subjects. Sulindac and its metabolites are not significantly removed from the blood in patients undergoing hemodialysis. Since Clinoril is eliminated primarily by the kidneys, patients with significantly impaired renal function should be closely monitored. A lower daily dosage should be anticipated to avoid excessive drug accumulation. Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a nonsteroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, patients who are volume-depleted and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state. Advanced Renal Disease No information is available from controlled clinical studies regarding the use of Clinoril in patients with advanced renal disease. Therefore, treatment with Clinoril is not recommended in these patients with advanced renal disease. If Clinoril therapy must be initiated, close monitoring of the patient's renal function is advisable. Voltaren - NSAID Caution should be used when initiating treatment with Voltaren in patients with considerable dehydration. Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a nonsteroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state. Any patient that is currently on dialysis should discuss any medications that are considering to incorporate in their daily regime with their doctor."